This study aimed to investigate changes in the solubility and antimicrobial efficacy of\ncefuroxime axetil (CA) when incorporated into cyclodextrin (CD). While choosing the CD, the validated\nin silico model was used. A theoretical model based on docking and molecular mechanics/generalized\nborn surface area was validated using a curated dataset of API (active pharmaceutical ingredient)â??CD\nstability constants. The library of commonly used cyclodextrins was virtually screened, indicating\nCA â??hydroxypropyl-BetaCD (HPBetaCD) as the most thermodynamically favored system. Solid-state\nCAâ??HPBetaCD system was prepared and characterized by differential scanning calorimetry (DSC),\nFourier-transform infrared (FT-IR), and X-ray diffraction (XRPD) methods. The dissolution profiles\nof the CA and its cyclodextrin system were evaluated. Microbiological activity of the CAâ??HPBetaCD\ninclusion system was studied based on changes in minimal inhibitory concentration (MIC) values\nand related to ones of the pure CA. The theoretical model was successfully validated, obtaining\nan average correlation with experimental data R = 0.7. The dissolution study showed significantly\nimproved dissolution profiles of CAâ??HPBetaCD compared to CA. HPBetaCD increases the antimicrobial\nefficacy of CA up to 4-fold compared to pure CA.
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